Journal of Pathology and Translational Medicine

Cheol Keun Park

7 Articles

A scoring system for the diagnosis of non-alcoholic steatohepatitis from liver biopsy: Kyoungbun Lee, Eun Sun Jung, Eunsil Yu, Yun Kyung Kang, Mee-Yon Cho, Joon Mee Kim, Woo Sung Moon, Jin Sook Jeong, Cheol Keun Park, Jae-Bok Park, Dae Young Kang, Jin Hee Sohn, So-Young Jin; J Pathol Transl Med. 2020;54(3):228-236. Published online April 15, 2020; DOI: https://doi.org/10.4132/jptm.2020.03.07

5,129 View
223 Download
2 Web of Science
3 Crossref

Background
Liver biopsy is the essential method to diagnose non-alcoholic steatohepatitis (NASH), but histological features of NASH are too subjective to achieve reproducible diagnoses in early stages of disease. We aimed to identify the key histological features of NASH and devise a scoring model for diagnosis.
Methods
Thirteen pathologists blindly assessed 12 histological factors and final histological diagnoses (‘not-NASH,’ ‘borderline,’ and ‘NASH’) of 31 liver biopsies that were diagnosed as non-alcoholic fatty liver disease (NAFLD) or NASH before and after consensus. The main histological parameters to diagnose NASH were selected based on histological diagnoses and the diagnostic accuracy and agreement of 12 scoring models were compared for final diagnosis and the NAFLD Activity Score (NAS) system.
Results
Inter-observer agreement of final diagnosis was fair (κ = 0.25) before consensus and slightly improved after consensus (κ = 0.33). Steatosis at more than 5% was the essential parameter for diagnosis. Major diagnostic factors for diagnosis were fibrosis except 1C grade and presence of ballooned cells. Minor diagnostic factors were lobular inflammation ( ≥ 2 foci/ × 200 field), microgranuloma, and glycogenated nuclei. All 12 models showed higher inter-observer agreement rates than NAS and post-consensus diagnosis (κ = 0.52–0.69 vs. 0.33). Considering the reproducibility of factors and practicability of the model, summation of the scores of major (× 2) and minor factors may be used for the practical diagnosis of NASH.
Conclusions
A scoring system for the diagnosis of NAFLD would be helpful as guidelines for pathologists and clinicians by improving the reproducibility of histological diagnosis of NAFLD.

Citations

Citations to this article as recorded by

Presurgery health influences outcomes following vertical sleeve gastrectomy in adolescents
Debi Swertfeger, Ahlee Kim, Hannah Sexmith, Maria E. Moreno‐Fernandez, W. Sean Davidson, Michael Helmrath, Todd Jenkins, Tsuyoshi Okura, Esmond Geh, Stavra A. Xanthakos, Sara Szabo, Takahisa Nakamura, Senad Divanovic, Amy Sanghavi Shah
Obesity.2024;[Epub] CrossRef
Changes in indications for outpatient percutaneous liver biopsy over 5 years: from hepatitis C to fatty liver disease
Marlone Cunha-Silva, Luíza D. Torres, Mariana F. Fernandes, Tirzah de M. Lopes Secundo, Marina C.G. Moreira, Ademar Yamanaka, Leonardo T. Monici, Larissa B. Eloy da Costa, Daniel F. Mazo, Tiago Sevá-Pereira
Gastroenterología y Hepatología.2022; 45(8): 579. CrossRef
Changes in indications for outpatient percutaneous liver biopsy over 5 years: from hepatitis C to fatty liver disease
Marlone Cunha-Silva, Luíza D. Torres, Mariana F. Fernandes, Tirzah de M. Lopes Secundo, Marina C.G. Moreira, Ademar Yamanaka, Leonardo T. Monici, Larissa B. Eloy da Costa, Daniel F. Mazo, Tiago Sevá-Pereira
Gastroenterología y Hepatología (English Edition).2022; 45(8): 579. CrossRef

IgG4-Related Sclerosing Mesenteritis: Seok Joo Lee, Cheol Keun Park, Woo Ick Yang, Sang Kyum Kim; J Pathol Transl Med. 2016;50(4):309-311. Published online January 11, 2016; DOI: https://doi.org/10.4132/jptm.2015.12.03

10,158 View
155 Download
12 Web of Science
15 Crossref

PDF

Citations

Citations to this article as recorded by

Manifestaciones toracoabdominales de las enfermedades relacionadas con la inmunoglobulina G4
M. Álvarez García, J.C. Álvarez Torices, M.J. Díez Liébana, M.R. de la Fuente Olmos
Radiología.2023; 65(2): 165. CrossRef
Thoracoabdominal manifestations of immunoglobulin G4-related disease
M. Álvarez García, J.C. Álvarez Torices, M.J. Díez Liébana, M.R. de la Fuente Olmos
Radiología (English Edition).2023; 65(2): 165. CrossRef
Systemic manifestations – do not forget the small bowel
Stefania Chetcuti Zammit, Reena Sidhu
Current Opinion in Gastroenterology.2021; 37(3): 234. CrossRef
A case of immunoglobulin G4-related sclerosing mesenteritis without other organ involvement
Masaya Kozono, Shiroh Tanoue, Kanna Kiyama, Kenichi Jikuya, Machiko Kawahira, Makoto Hinokuchi, Hiromichi Iwaya, Shiho Arima, Shinichi Hashimoto, Kiyokazu Hiwatashi, Yoshio Fukuda, Masahiko Sakoda, Michiyo Higashi, Koichi Tokushige, Akio Ido
Clinical Journal of Gastroenterology.2021; 14(5): 1411. CrossRef
Sclerosing Mesenteritis Mimicking IgG4-related Disease
Masahide Fukuda, Toru Miyake, Akiko Matsubara, Nobuyasu Ikai, Eri Tanaka, Tomo Namura, Yasuhiro Wada, Mai Noujima, Suzuko Moritani, Kazunari Murakami, Akira Andoh, Masaji Tani, Ryoji Kushima
Internal Medicine.2020; 59(4): 513. CrossRef
A rare case report of immunoglobulin G4-related sclerosing mesenteritis and review of the literature
Zhicheng Liu, Yan Jiao, Liang He, Helei Wang, Daguang Wang
Medicine.2020; 99(41): e22579. CrossRef
Calcifying fibrous tumor of the gastrointestinal tract: A clinicopathologic review and update
Donald Turbiville, Xu-Chen Zhang
World Journal of Gastroenterology.2020; 26(37): 5597. CrossRef
Immunoglobulin G4 Unrelated Idiopathic Mesenteric Sclerosis
Tae Hyung Kwon, Kwang Bum Cho, Hyun Jik Lee, Sun Young Kwon, Yoon Suk Lee
The Korean Journal of Gastroenterology.2019; 73(1): 50. CrossRef
A Case of IgG4-related Sclerosing Mesenteritis Causing Intestinal Perforation
Junich SAKAMOTO, Masahiko WATANABE
Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association).2019; 80(9): 1658. CrossRef
„Misty mesentery“
L. P. Beyer, A. Schreyer
Der Radiologe.2018; 58(1): 56. CrossRef
IgG4-Related Disease Mimicking Crohn’s Disease: A Case Report and Review of Literature
Fabiana Ciccone, Antonio Ciccone, Mirko Di Ruscio, Filippo Vernia, Gianluca Cipolloni, Gino Coletti, Giuseppe Calvisi, Giuseppe Frieri, Giovanni Latella
Digestive Diseases and Sciences.2018; 63(4): 1072. CrossRef
Mesenteric tumour deposits arising from small‐intestine neuroendocrine tumours are frequently associated with fibrosis and IgG4‐expressing plasma cells
Jordan Roberts, Raul S Gonzalez, Frank Revetta, Chanjuan Shi
Histopathology.2018; 73(5): 795. CrossRef
A Case Report of Probable Diagnosis Group of IgG4-related Sclerosing Mesenteritis
Daiki YOKOYAMA, Takayuki TAJIMA, Masaya MUKAI, Shuji UDA, Shinichiroh HIRAIWA, Takuma TAJIRI, Eiji NOMURA, Hiroyasu MAKUUCHI
Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association).2017; 78(10): 2245. CrossRef
Serosal involvement in IgG4-related disease: report of two cases and review of the literature
Juan González-Moreno, Inés Losada-López, Cristina Gállego-Lezaun, Mercedes García-Gasalla, Cristina Gómez Bellvert, Norberto Ortego Centeno
Rheumatology International.2016; 36(7): 1033. CrossRef
IgG4-related sclerosing mesenteritis causing bowel obstruction: a case report
Atsushi Abe, Tatsuya Manabe, Nobuyoshi Takizawa, Takashi Ueki, Daisuke Yamada, Kinuko Nagayoshi, Yoshihiko Sadakari, Hayato Fujita, Shuntaro Nagai, Hidetaka Yamamoto, Yoshinao Oda, Masafumi Nakamura
Surgical Case Reports.2016;[Epub] CrossRef

Soft Tissue Roasi-Dorfman Disease with Features of IgG4-Related Disease in a Patient with a History of Acute Myeloid Leukemia: Cheol Keun Park, Eun Kyung Kim, Ji-Ye Kim, Hayoung Woo, Mi Jang, Hyang Sook Jeong, Woo Ick Yang, Sang Kyum Kim; J Pathol Transl Med. 2016;50(3):246-249. Published online November 17, 2015; DOI: https://doi.org/10.4132/jptm.2015.10.08

7,055 View
58 Download

PDF

Pathologic Evaluation of Breast Cancer after Neoadjuvant Therapy: Cheol Keun Park, Woo-Hee Jung, Ja Seung Koo; J Pathol Transl Med. 2016;50(3):173-180. Published online April 11, 2016; DOI: https://doi.org/10.4132/jptm.2016.02.02

13,018 View
441 Download
32 Web of Science
30 Crossref

Abstract PDF

Breast cancer, one of the most common cancers in women, has various treatment modalities. Neoadjuvant therapy (NAT) has been used in many clinical trials because it is easy to evaluate the treatment response to therapeutic agents in a short time period; consequently, NAT is currently a standard treatment modality for large-sized and locally advanced breast cancers, and its use in early-stage breast cancer is becoming more common. Thus, chances to encounter breast tissue from patients treated with NAT is increasing. However, systems for handling and evaluating such specimens have not been established. Several evaluation systems emphasize a multidisciplinary approach to increase the accuracy of breast cancer assessment. Thus, detailed and systematic evaluation of clinical, radiologic, and pathologic findings is important. In this review, we compare the major problems of each evaluation system and discuss important points for handling and evaluating NAT-treated breast specimens.

Citations

Citations to this article as recorded by

Good practice: The experiences with the utilization of residual cancer burden—A single institution study
Anita Sejben, Fanni Hegedűs, Szintia Almási, Márton Berta, Orsolya Oláh‐Németh, Tamás Zombori
Thoracic Cancer.2023; 14(11): 963. CrossRef
Assessing the Correlation of Rate of Pathological Complete Response and Outcome in Post Neoadjuvant Chemotherapy Setting and Molecular Subtypes of Breast Cancer
Ahmad Omair, Abdulmohsen Alkushi, Ghaida Alamri, Talal Almojel, Sara Alsadun, Emad Masuadi, Haitham Arabi, Amin E Mohamed, Omalkhair A Abulkhair
Cureus.2023;[Epub] CrossRef
Compression OCT-elastography combined with speckle-contrast analysis as an approach to the morphological assessment of breast cancer tissue
Anton A. Plekhanov, Ekaterina V. Gubarkova, Marina A. Sirotkina, Alexander A. Sovetsky, Dmitry A. Vorontsov, Lev A. Matveev, Sergey S. Kuznetsov, Alexandra Y. Bogomolova, Alexey Y. Vorontsov, Alexander L. Matveyev, Sergey V. Gamayunov, Elena V. Zagaynova,
Biomedical Optics Express.2023; 14(6): 3037. CrossRef
Ambiguity-aware breast tumor cellularity estimation via self-ensemble label distribution learning
Xiangyu Li, Xinjie Liang, Gongning Luo, Wei Wang, Kuanquan Wang, Shuo Li
Medical Image Analysis.2023; 90: 102944. CrossRef
Concurrent Chemo-radiation As a Means of Achieving Pathologic Complete Response in Triple Negative Breast Cancer
Maryam Nemati Shafaee, Shalini Makawita, Bora Lim, Matthew J Ellis, Michelle S Ludwig
Clinical Breast Cancer.2022; 22(4): e536. CrossRef
Pathology after neoadjuvant treatment – How to assess residual disease
Giuseppe Viale, Nicola Fusco
The Breast.2022; 62: S25. CrossRef
Efficacy Evaluation of Neoadjuvant Chemotherapy in Breast Cancer by MRI
Yongguang Liu, Mingxiang Wu, Wenyong Tan, Jingshan Gong, Jie Ma, Mohammad Farukh Hashmi
Contrast Media & Molecular Imaging.2022; 2022: 1. CrossRef
Predictive Role of Soluble IL-6R, TNF-R1/2, and Cell Adhesion Molecules Serum Levels in the Preoperative and Adjuvant Therapy in Women with Nonmetastatic Breast Cancer: A Preliminary Study
Weronika Bulska-Będkowska, Paulina Czajka-Francuz, Sylwia Cisoń-Jurek, Aleksander J. Owczarek, Tomasz Francuz, Jerzy Chudek
Journal of Interferon & Cytokine Research.2022; 42(11): 557. CrossRef
The prognostic role of lymph node ratio in breast cancer patients received neoadjuvant chemotherapy: A dose-response meta-analysis
Jinzhao Liu, Yifei Li, Weifang Zhang, Chenhui Yang, Chao Yang, Liang Chen, Mingjian Ding, Liang Zhang, Xiaojun Liu, Guozhong Cui, Yunjiang Liu
Frontiers in Surgery.2022;[Epub] CrossRef
The Role of miR-375-3p, miR-210-3p and Let-7e-5p in the Pathological Response of Breast Cancer Patients to Neoadjuvant Therapy
Lorena Alexandra Lisencu, Andrei Roman, Simona Visan, Eduard-Alexandru Bonci, Andrei Pașca, Emilia Grigorescu, Elena Mustea, Andrei Cismaru, Alexandru Irimie, Cosmin Lisencu, Loredana Balacescu, Ovidiu Balacescu, Oana Tudoran
Medicina.2022; 58(10): 1494. CrossRef
Post-Neoadjuvant Treatment Strategies for Patients with Early Breast Cancer
Elisa Agostinetto, Flavia Jacobs, Véronique Debien, Alex De Caluwé, Catalin-Florin Pop, Xavier Catteau, Philippe Aftimos, Evandro de Azambuja, Laurence Buisseret
Cancers.2022; 14(21): 5467. CrossRef
Tumor Microenvironment in Breast Cancer—Updates on Therapeutic Implications and Pathologic Assessment
Joshua J. Li, Julia Y. Tsang, Gary M. Tse
Cancers.2021; 13(16): 4233. CrossRef
SPIE-AAPM-NCI BreastPathQ challenge: an image analysis challenge for quantitative tumor cellularity assessment in breast cancer histology images following neoadjuvant treatment
Nicholas Petrick, Shazia Akbar, Kenny H. Cha, Sharon Nofech-Mozes, Berkman Sahiner, Marios A. Gavrielides, Jayashree Kalpathy-Cramer, Karen Drukker, Anne L. Martel, for the BreastPathQ Challenge Group
Journal of Medical Imaging.2021;[Epub] CrossRef
Diagnostic performance of digital breast tomosynthesis for predicting response to neoadjuvant systemic therapy in breast cancer patients: A comparison with magnetic resonance imaging, ultrasound, and full-field digital mammography
Ryusuke Murakami, Hitomi Tani, Shinichiro Kumita, Nachiko Uchiyama
Acta Radiologica Open.2021; 10(12): 205846012110637. CrossRef
Los márgenes
Laia Bernet, María Angeles Montero Fernández
Revista de Senología y Patología Mamaria.2021; 34: S25. CrossRef
Neoadjuvant chemotherapy in non‐metastatic breast cancer: a study on practice trends in a regional cancer treatment service
Edmond Ang, Navin Wewala, Rebecca Carroll, Garry Forgeson, Malcolm Anderson, Jennifer Fernando, Jody Jordan, Richard Isaacs
Internal Medicine Journal.2020; 50(3): 315. CrossRef
Examination of Tumor Regression Grading Systems in Breast Cancer Patients Who Received Neoadjuvant Therapy
Anita Sejben, Renáta Kószó, Zsuzsanna Kahán, Gábor Cserni, Tamás Zombori
Pathology & Oncology Research.2020; 26(4): 2747. CrossRef
Integrating evolutionary dynamics into cancer therapy
Robert A. Gatenby, Joel S. Brown
Nature Reviews Clinical Oncology.2020; 17(11): 675. CrossRef
Assessing the accuracy of conventional gadolinium‐enhanced breast MRI in measuring the nodal response to neoadjuvant chemotherapy (NAC) in breast cancer
Lisa Christine Murphy, Edel Marie Quinn, Zeeshan Razzaq, Claire Brady, Vicki Livingstone, Lorna Duddy, Josephine Barry, Henry Paul Redmond, Mark Anthony Corrigan
The Breast Journal.2020; 26(11): 2151. CrossRef
Early prediction of neoadjuvant chemotherapy response for advanced breast cancer using PET/MRI image deep learning
Joon Ho Choi, Hyun-Ah Kim, Wook Kim, Ilhan Lim, Inki Lee, Byung Hyun Byun, Woo Chul Noh, Min-Ki Seong, Seung-Sook Lee, Byung Il Kim, Chang Woon Choi, Sang Moo Lim, Sang-Keun Woo
Scientific Reports.2020;[Epub] CrossRef
Patterns of Regression in Breast Cancer after Primary Systemic Treatment
Tamás Zombori, Gábor Cserni
Pathology & Oncology Research.2019; 25(3): 1153. CrossRef
The Role of Neutrophil-lymphocyte Ratio and Platelet-lymphocyte Ratio in Predicting Neoadjuvant Chemotherapy Response in Breast Cancer
Hee Yeon Kim, Tae Hyun Kim, Hye Kyoung Yoon, Anbok Lee
Journal of Breast Cancer.2019; 22(3): 425. CrossRef
Higher underestimation of tumour size post-neoadjuvant chemotherapy with breast magnetic resonance imaging (MRI)—A concordance comparison cohort analysis
Wen-Pei Wu, Hwa-Koon Wu, Chih-Jung Chen, Chih-Wie Lee, Shou-Tung Chen, Dar-Ren Chen, Chen-Te Chou, Chi Wei Mok, Hung-Wen Lai, Pascal A. T. Baltzer
PLOS ONE.2019; 14(10): e0222917. CrossRef
Multimodal image-guided surgery of HER2-positive breast cancer using [111In]In-DTPA-trastuzumab-IRDye800CW in an orthotopic breast tumor model
Marion M. Deken, Desirée L. Bos, Willemieke S. F. J. Tummers, Taryn L. March, Cornelis J. H. van de Velde, Mark Rijpkema, Alexander L. Vahrmeijer
EJNMMI Research.2019;[Epub] CrossRef
Mammographic density is a potential predictive marker of pathological response after neoadjuvant chemotherapy in breast cancer
Ida Skarping, Daniel Förnvik, Hanna Sartor, Uffe Heide-Jørgensen, Sophia Zackrisson, Signe Borgquist
BMC Cancer.2019;[Epub] CrossRef
ALDH1 and tumor infiltrating lymphocytes as predictors for neoadjuvant chemotherapy response in breast cancer
Anbok Lee, Kyu Yeoun Won, Sung-Jig Lim, Sun Young Cho, Sang-Ah Han, SaeGwang Park, Jeong-Yoon Song
Pathology - Research and Practice.2018; 214(5): 619. CrossRef
Early Prediction of Response to Neoadjuvant Chemotherapy Using Dynamic Contrast-Enhanced MRI and Ultrasound in Breast Cancer
Yunju Kim, Sung Hun Kim, Byung Joo Song, Bong Joo Kang, Kwang-il Yim, Ahwon Lee, Yoonho Nam
Korean Journal of Radiology.2018; 19(4): 682. CrossRef
Outcomes of neoadjuvant and adjuvant chemotherapy in stage 2 and 3 non-small cell lung cancer: an analysis of the National Cancer Database
Matthew MacLean, Xin Luo, Shidan Wang, Kemp Kernstine, David E. Gerber, Yang Xie
Oncotarget.2018; 9(36): 24470. CrossRef
Automatic cellularity assessment from post‐treated breast surgical specimens
Mohammad Peikari, Sherine Salama, Sharon Nofech‐Mozes, Anne L. Martel
Cytometry Part A.2017; 91(11): 1078. CrossRef
The importance of tissue confirmation of metastatic disease in patients with breast cancer: lesson from a brain metastasis case
Jingxian Ding, Pinghua Hu, Jun Chen, Xiaobo Wu, Yali Cao
Oncoscience.2016; 3(9-10): 268. CrossRef

Interobserver Agreement on Pathologic Features of Liver Biopsy Tissue in Patients with Nonalcoholic Fatty Liver Disease: Eun Sun Jung, Kyoungbun Lee, Eunsil Yu, Yun Kyung Kang, Mee-Yon Cho, Joon Mee Kim, Woo Sung Moon, Jin Sook Jeong, Cheol Keun Park, Jae-Bok Park, Dae Young Kang, Jin Hee Sohn, So-Young Jin; J Pathol Transl Med. 2016;50(3):190-196. Published online April 18, 2016; DOI: https://doi.org/10.4132/jptm.2016.03.01

10,503 View
240 Download
23 Web of Science
22 Crossref

Abstract PDF

Background
The histomorphologic criteria for the pathological features of liver tissue from patients with non-alcoholic fatty liver disease (NAFLD) remain subjective, causing confusion among pathologists and clinicians. In this report, we studied interobserver agreement of NAFLD pathologic features and analyzed causes of disagreement.
Methods
Thirty-one cases of clinicopathologically diagnosed NAFLD from 10 hospitals were selected. One hematoxylin and eosin and one Masson’s trichrome-stained virtual slide from each case were blindly reviewed with regard to 12 histological parameters by 13 pathologists in a gastrointestinal study group of the Korean Society of Pathologists. After the first review, we analyzed the causes of disagreement and defined detailed morphological criteria. The glass slides from each case were reviewed a second time after a consensus meeting. The degree of interobserver agreement was determined by multi-rater kappa statistics.
Results
Kappa values of the first review ranged from 0.0091–0.7618. Acidophilic bodies (k = 0.7618) and portal inflammation (k = 0.5914) showed high levels of agreement, whereas microgranuloma (k = 0.0984) and microvesicular fatty change (k = 0.0091) showed low levels of agreement. After the second review, the kappa values of the four major pathological features increased from 0.3830 to 0.5638 for steatosis grade, from 0.1398 to 0.2815 for lobular inflammation, from 0.1923 to 0.3362 for ballooning degeneration, and from 0.3303 to 0.4664 for fibrosis.
Conclusions
More detailed histomorphological criteria must be defined for correct diagnosis and high interobserver agreement of NAFLD.

Citations

Citations to this article as recorded by

Non-alcoholic fatty liver disease: the pathologist’s perspective
Wei-Qiang Leow, Anthony Wing-Hung Chan, Paulo Giovanni L. Mendoza, Regina Lo, Kihan Yap, Haeryoung Kim
Clinical and Molecular Hepatology.2023; 29(Suppl): S302. CrossRef
CT-based Hounsfield unit values reflect the degree of steatohepatitis in patients with low-grade fatty liver disease
Ha Neul Kim, Hong Jae Jeon, Hei Gwon Choi, In Sun Kwon, Woo Sun Rou, Jeong Eun Lee, Tae Hee Lee, Seok Hyun Kim, Byung Seok Lee, Kyung Sook Shin, Hyun Jung Lee, Hyuk Soo Eun
BMC Gastroenterology.2023;[Epub] CrossRef
Artificial intelligence and deep learning: New tools for histopathological diagnosis of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis
Yoshihisa Takahashi, Erdenetsogt Dungubat, Hiroyuki Kusano, Toshio Fukusato
Computational and Structural Biotechnology Journal.2023; 21: 2495. CrossRef
An integrated gene-to-outcome multimodal database for metabolic dysfunction-associated steatotic liver disease
Timothy J. Kendall, Maria Jimenez-Ramos, Frances Turner, Prakash Ramachandran, Jessica Minnier, Michael D. McColgan, Masood Alam, Harriet Ellis, Donald R. Dunbar, Gabriele Kohnen, Prakash Konanahalli, Karin A. Oien, Lucia Bandiera, Filippo Menolascina, An
Nature Medicine.2023; 29(11): 2939. CrossRef
Artificial intelligence scoring of liver biopsies in a phase II trial of semaglutide in nonalcoholic steatohepatitis
Vlad Ratziu, Sven Francque, Cynthia A. Behling, Vanja Cejvanovic, Helena Cortez-Pinto, Janani S. Iyer, Niels Krarup, Quang Le, Anne-Sophie Sejling, Dina Tiniakos, Stephen A. Harrison
Hepatology.2023;[Epub] CrossRef
Improved pathology reporting in NAFLD/NASH for clinical trials
Caitlin Rose Langford, Marc H Goldinger, Darren Treanor, Clare McGenity, Jonathan R Dillman, Daniela S Allende, Robert Goldin, Elizabeth M Brunt, Kurt Zatloukal, Helmut Denk, Kenneth A Fleming
Journal of Clinical Pathology.2022; 75(2): 73. CrossRef
Standardizing the histological assessment of late posttransplantation biopsies from pediatric liver allograft recipients
Stefan G. Hübscher, Sandy Feng, Annette S. H. Gouw, Hironori Haga, Hyo Jeong Kang, Deirdre A. Kelly, Mina Komuta, Andrew Lesniak, Benjamin A. Popp, Henkjan J. Verkade, Eunsil Yu, Anthony J. Demetris
Liver Transplantation.2022; 28(9): 1475. CrossRef
Discordant pathological diagnosis of non‐alcoholic fatty liver disease: A prospective multicenter study
Takuya Kuwashiro, Hirokazu Takahashi, Hideyuki Hyogo, Yuji Ogawa, Kento Imajo, Masato Yoneda, Takashi Nakahara, Satoshi Oeda, Kenichi Tanaka, Yuichiro Amano, Shinji Ogawa, Atsushi Kawaguchi, Shinichi Aishima, Masayoshi Kage, Kazuaki Chayama, Atsushi Nakaj
JGH Open.2020; 4(3): 497. CrossRef
Obeticholic acid for the treatment of nonalcoholic steatohepatitis: Expectations and concerns
Stergios A. Polyzos, Jannis Kountouras, Christos S. Mantzoros
Metabolism.2020; 104: 154144. CrossRef
A scoring system for the diagnosis of non-alcoholic steatohepatitis from liver biopsy
Kyoungbun Lee, Eun Sun Jung, Eunsil Yu, Yun Kyung Kang, Mee-Yon Cho, Joon Mee Kim, Woo Sung Moon, Jin Sook Jeong, Cheol Keun Park, Jae-Bok Park, Dae Young Kang, Jin Hee Sohn, So-Young Jin
Journal of Pathology and Translational Medicine.2020; 54(3): 228. CrossRef
An Improved qFibrosis Algorithm for Precise Screening and Enrollment into Non-Alcoholic Steatohepatitis (NASH) Clinical Trials
Wei-Qiang Leow, Pierre Bedossa, Feng Liu, Lai Wei, Kiat-Hon Lim, Wei-Keat Wan, Yayun Ren, Jason Pik-Eu Chang, Chee-Kiat Tan, Aileen Wee, George Boon-Bee Goh
Diagnostics.2020; 10(9): 643. CrossRef
Deep learning quantification of percent steatosis in donor liver biopsy frozen sections
Lulu Sun, Jon N. Marsh, Matthew K. Matlock, Ling Chen, Joseph P. Gaut, Elizabeth M. Brunt, S. Joshua Swamidass, Ta-Chiang Liu
EBioMedicine.2020; 60: 103029. CrossRef
Magnetic resonance elastography SE-EPI vs GRE sequences at 3T in a pediatric population with liver disease
Juan S. Calle-Toro, Suraj D. Serai, Erum A. Hartung, David J. Goldberg, Bradley D. Bolster, Kassa Darge, Sudha A. Anupindi
Abdominal Radiology.2019; 44(3): 894. CrossRef
R2 relaxometry based MR imaging for estimation of liver iron content: A comparison between two methods
Juan S. Calle-Toro, Christian A. Barrera, Dmitry Khrichenko, Hansel J. Otero, Suraj D. Serai
Abdominal Radiology.2019; 44(9): 3058. CrossRef
Inhibition of mitochondrial fatty acid oxidation in drug-induced hepatic steatosis
Bernard Fromenty
Liver Research.2019; 3(3-4): 157. CrossRef
Standardising the interpretation of liver biopsies in non‐alcoholic fatty liver disease clinical trials
Rish K. Pai, David E. Kleiner, John Hart, Oyedele A. Adeyi, Andrew D. Clouston, Cynthia A. Behling, Dhanpat Jain, Sanjay Kakar, Mayur Brahmania, Lawrence Burgart, Kenneth P. Batts, Mark A. Valasek, Michael S. Torbenson, Maha Guindi, Hanlin L. Wang, Veeral
Alimentary Pharmacology & Therapeutics.2019; 50(10): 1100. CrossRef
NAFLD Histology: a Critical Review and Comparison of Scoring Systems
Rish K. Pai
Current Hepatology Reports.2019; 18(4): 473. CrossRef
Hepatic sonic hedgehog protein expression measured by computer assisted morphometry significantly correlates with features of non-alcoholic steatohepatitis
Michael Estep, Rohini Mehta, Gary Bratthauer, Lakshmi Alaparthi, Fanny Monge, Simon Ali, Dinan Abdelatif, Zahra Younoszai, Maria Stepanova, Zachary D. Goodman, Zobair M. Younossi
BMC Gastroenterology.2019;[Epub] CrossRef
Validation of intimate correlation between visceral fat and hepatic steatosis: Quantitative measurement techniques using CT for area of fat and MR for hepatic steatosis
Moon Hyung Choi, Joon-Il Choi, Michael Yong Park, Sung Eun Rha, Soon Nam Oh, Seung Eun Jung, Jae Young Byun, Stephan Kannengiesser, Yohan Son
Clinical Nutrition.2018; 37(1): 214. CrossRef
Ultrasound or MR elastography of liver: which one shall I use?
Meng Yin, Sudhakar K. Venkatesh
Abdominal Radiology.2018; 43(7): 1546. CrossRef
Feasibility and agreement of stiffness measurements using gradient-echo and spin-echo MR elastography sequences in unselected patients undergoing liver MRI
Guilherme Moura Cunha, Kevin J Glaser, Anke Bergman, Rodrigo P Luz, Eduardo H de Figueiredo, Flavia Paiva Proença Lobo Lopes
The British Journal of Radiology.2018; : 20180126. CrossRef
Second harmonic generation microscopy provides accurate automated staging of liver fibrosis in patients with non-alcoholic fatty liver disease
Pik Eu Chang, George Boon Bee Goh, Wei Qiang Leow, Liang Shen, Kiat Hon Lim, Chee Kiat Tan, Manlio Vinciguerra
PLOS ONE.2018; 13(6): e0199166. CrossRef

Silent Colonic Malakoplakia in a Living-Donor Kidney Transplant Recipient Diagnosed during Annual Medical Examination: Go Eun Bae, Nara Yoon, Ha Young Park, Sang Yun Ha, Junhun Cho, Yunkyung Lee, Kyoung-Mee Kim, Cheol Keun Park; Korean J Pathol. 2013;47(2):163-166. Published online April 24, 2013; DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.2.163

6,230 View
56 Download
8 Crossref

Abstract PDF

Malakoplakia is a characteristic inflammatory condition, which is usually seen in the urogenital tract, and less frequently in the gastrointestinal tract. We present a case of colonic malakoplakia in an immunocompromised patient. A 55-year-old female visited the outpatient clinic for routine cancer surveillance. Her past medical history was significant for kidney transplantation 11 years ago, and she had been taking immunosuppressants. A colonoscopy revealed several depressed flat lesions and elevated polyps, which were 0.3 to 0.4 cm in size and accompanied by whitish exudates. A biopsy revealed an infiltration of histiocytes with ample granular eosinophilic cytoplasm, with some lymphocytes and plasma cells. Many histiocytes had the characteristic morphology, described as Michaelis-Gutmann bodies: one or several round basophilic structures of approximately 1 to 10 µm in size with some being laminated, some appearing homogeneous, and others having a dense central core with a targetoid appearance. These Michaelis-Gutmann bodies were positively stained on von Kossa stain, and were diagnostic for malakoplakia.

Citations

Citations to this article as recorded by

Caecal malakoplakia: a rare mimic of malignancy
Jeffrey Li Voon Chong, Noor Ali
BMJ Case Reports.2024; 17(1): e257130. CrossRef
A Surgical Challenge Generated by Colonic Malakoplakia in Disguise as a Locally Advanced Colonic Malignancy—A Case Report
Cristina Șerban, Alexandra Toma, Dragoș Cristian Voicu, Constantin Popazu, Dorel Firescu, George Țocu, Raul Mihailov, Laura Rebegea
Medicina.2023; 59(1): 156. CrossRef
Colonic malakoplakia in a cardiac transplant recipient: A case report
Sadiya Shafijan
Indian Journal of Pathology and Microbiology.2020; 63(2): 322. CrossRef
Immunosuppressive drugs and the gastrointestinal tract in renal transplant patients
Merel M. Tielemans, Gerben A.J. van Boekel, Teun van Gelder, Eric T. Tjwa, Luuk B. Hilbrands
Transplantation Reviews.2019; 33(2): 55. CrossRef
Malakoplakia of the colon following renal transplantation in a 73 year old woman: report of a case presenting as intestinal perforation
Andrew Mitchell, Alexandre Dugas
Diagnostic Pathology.2019;[Epub] CrossRef
Colonic malakoplakia in a liver transplant recipient: A case report
Rana Ajabnoor, Mohammad Mawardi, Abdulmonem Almutawa
Human Pathology: Case Reports.2019; 18: 200323. CrossRef
Malakoplakia after kidney transplantation: Case report and literature review
John Fredy Nieto‐Ríos, Isabel Ramírez, Mónica Zuluaga‐Quintero, Lina María Serna‐Higuita, Federico Gaviria‐Gil, Alejandro Velez‐Hoyos
Transplant Infectious Disease.2017;[Epub] CrossRef
Megalocytic Interstitial Nephritis Following Acute Pyelonephritis with Escherichia coli Bacteremia: A Case Report
Hee Jin Kwon, Kwai Han Yoo, In Young Kim, Seulkee Lee, Hye Ryoun Jang, Ghee Young Kwon
Journal of Korean Medical Science.2015; 30(1): 110. CrossRef

Gastric Adenocarcinoma of Fundic Gland Type: Report of Three Cases: Eun Su Park, Young Eun Kim, Cheol Keun Park, Takashi Yao, Ryoji Kushima, Kyoung-Mee Kim; Korean J Pathol. 2012;46(3):287-291. Published online June 22, 2012; DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.3.287

9,166 View
98 Download
23 Crossref

Abstract PDF

Recently, fundic gland type gastric adenocarcinoma (GA-FG) has been reported as a new entity. This report describes GA-FG among Koreans for the first time. From March 2008 to July 2010 we identified only three cases of GA-FG out of over 6,000 GAs resected by endoscopy or surgery. Cell differentiation by mucin proteins, pepsinogen-I, and H+/K+-ATPase was evaluated. All three cases were male patients and diagnosed as early stage GA. Histologically, GA-FGs were well-differentiated adenocarcinoma with pale gray-blue, basophilic columnar or cuboidal cells and mildly enlarged nuclei, resembling chief cells. All three cases were positive for pepsinogen-I and were classified as gastric mucin phenotype. Among three histologic subtypes of GA-FG, since tumors were mainly composed of chief cells, our three cases were classified as chief cell predominant type. In conclusion, GA-FG is very rare among Koreans and pepsinogen-I and MUC6 expression are typical immunohistochemical findings in GA-FG suggesting differentiation toward fundic glands.

Citations

Citations to this article as recorded by

Transcriptome analysis reveals the essential role of NK2 homeobox 1/thyroid transcription factor 1 (NKX2-1/TTF-1) in gastric adenocarcinoma of fundic-gland type
Kazushi Fukagawa, Yu Takahashi, Nobutake Yamamichi, Natsuko Kageyama-Yahara, Yoshiki Sakaguchi, Miho Obata, Rina Cho, Nobuyuki Sakuma, Sayaka Nagao, Yuko Miura, Naoki Tamura, Daisuke Ohki, Hiroya Mizutani, Seiichi Yakabi, Chihiro Minatsuki, Keiko Niimi, Y
Gastric Cancer.2023; 26(1): 44. CrossRef
Clinicopathological Features and the Prevalence of Oxyntic Gland Neoplasm: A Single-center Retrospective Study
Hikari Asahara, Toshitatsu Takao, Yumiko Asahara, Masakyo Asahara, Douglas Motomura, Hiroya Sakaguchi, Tetsuya Yoshizaki, Nobuaki Ikezawa, Madoka Takao, Yoshinori Morita, Takashi Toyonaga, Masato Komatsu, Ryoji Kushima, Yuzo Kodama
Internal Medicine.2023; 62(19): 2763. CrossRef
Clinicopathological features of gastric adenocarcinoma of fundic gland type
Bao-Zhen Guo, Zhen-Zhen Liu, Gao-Fei Shen, Fei Zhu, Hui-Fen Lian, Xin Li, Jun-Yi Zheng, Jin-Peng Li, Shui-Miao Deng, Rui Huang
World Chinese Journal of Digestology.2023; 31(6): 244. CrossRef
Endoscopic Resection for Gastric Adenocarcinoma of the Fundic Gland Type: A Case Series
Hwa Jin Lee, Gwang Ha Kim, Dong Chan Joo, Moon Won Lee, Bong Eun Lee, Kyungbin Kim
The Korean Journal of Gastroenterology.2023; 81(6): 259. CrossRef
Gastric adenocarcinoma of the fundic gland type: A review of the literature
Zhiyong Zhai, Wei Hu, Zhaoyu Huang, Zemin Chen, Sicun Lu, Wei Gong
JGH Open.2023; 7(12): 812. CrossRef
Clinicopathological features of early stage gastric adenocarcinoma of fundic gland type
Huan Zhang, Shuyan Wang, Yongping Zhang, Fusang Ye, Chunnian Wang
Medicine.2022; 101(2): e28469. CrossRef
Gastric Adenocarcinoma of Fundic Gland Type Treated by Endoscopic Submucosal Dissection
Yong Bo Park, Gwang Ha Kim, Kyungbin Kim, Tae Kyoung Ha, Guk Bin Park, Young Min Kwak
The Korean Journal of Helicobacter and Upper Gastrointestinal Research.2021; 21(1): 82. CrossRef
Gastric epithelial neoplasm of fundic-gland mucosa lineage: proposal for a new classification in association with gastric adenocarcinoma of fundic-gland type
Hiroya Ueyama, Takashi Yao, Yoichi Akazawa, Takuo Hayashi, Koichi Kurahara, Yumi Oshiro, Masayoshi Yamada, Ichiro Oda, Shin Fujioka, Chiaki Kusumoto, Masayoshi Fukuda, Kunihisa Uchita, Tomohiro Kadota, Yasuhiro Oono, Kazuhisa Okamoto, Kazunari Murakami, Y
Journal of Gastroenterology.2021; 56(9): 814. CrossRef
Endoscopic resection is a suitable initial treatment strategy for oxyntic gland adenoma or gastric adenocarcinoma of the fundic gland type
Masaya Iwamuro, Chiaki Kusumoto, Masahiro Nakagawa, Sayo Kobayashi, Masao Yoshioka, Tomoki Inaba, Tatsuya Toyokawa, Shinichiro Hori, Shouichi Tanaka, Kazuhiro Matsueda, Takehiro Tanaka, Hiroyuki Okada
Scientific Reports.2021;[Epub] CrossRef
A series of five patients with oxyntic gland adenoma: Deciphering the clinical and histological features of these rare gastric polyps
Jerry C. Nagaputra, Tracy Jie Zhen Loh, Sangeeta Mantoo, Rafay Azhar, Vikneswaran Namasivayam, Wei Qiang Leow
Human Pathology Reports.2021; 26: 300566. CrossRef
Gastric adenocarcinoma of the fundic gland: A review of clinicopathological characteristics, treatment and prognosis
Xiang-yu Meng, Guang Yang, Cheng-ji Dong, Ru-yi Zheng
Rare Tumors.2021; 13: 203636132110601. CrossRef
Gastric adenocarcinoma of the fundic gland type: clinicopathological features of eight patients treated with endoscopic submucosal dissection
Chengfang Li, Xinglong Wu, Shuang Yang, Xiaorong Yang, Jin Yao, Hong Zheng
Diagnostic Pathology.2020;[Epub] CrossRef
Multiple gastric adenocarcinoma of fundic gland type: A case report
Ou Chen, Ze-Yong Shao, Xiong Qiu, Guang-Ping Zhang
World Journal of Clinical Cases.2019; 7(18): 2871. CrossRef
Gastric Adenocarcinoma of the Fundic Gland Type
Mark A Benedict, Gregory Y Lauwers, Dhanpat Jain
American Journal of Clinical Pathology.2018; 149(6): 461. CrossRef
Oxyntic Gland Adenoma Treated by Endoscopic Mucosal Resection
In Ji Song, Jin Woo Joo, Jun Chul Park, Sung Kwan Shin, Yong Chan Lee, Sang Kil Lee
The Korean Journal of Helicobacter and Upper Gastrointestinal Research.2017; 17(2): 94. CrossRef
Chief cell‐predominant gastric polyps: a series of 12 cases with literature review
Karen Chan, Ian S Brown, Trevor Kyle, Gregory Y Lauwers, Marian Priyanthi Kumarasinghe
Histopathology.2016; 68(6): 825. CrossRef
Twelve-year natural history of a gastric adenocarcinoma of fundic gland type
Yoshinori Sato, Takashi Fujino, Akira Kasagawa, Ryo Morita, Shun-ichiro Ozawa, Yasumasa Matsuo, Tadateru Maehata, Hiroshi Yasuda, Masayuki Takagi, Fumio Itoh
Clinical Journal of Gastroenterology.2016; 9(6): 345. CrossRef
Clinicopathological features of gastric adenocarcinoma of the fundic gland (chief cell predominant type) by retrospective and prospective analyses of endoscopic findings
Takashi Chiba, Katsuaki Kato, Takayuki Masuda, Shuichi Ohara, Noriyuki Iwama, Takenobu Shimada, Daisuke Shibuya
Digestive Endoscopy.2016; 28(7): 722. CrossRef
Gastric Adenocarcinoma of the Fundic Gland Type Treated by Endoscopic Mucosal Resection: A Case Report and Review of the Literature
Eleanor Lewin, Philip Daroca, Sanjay Sikka, Tong Wu, Yukihiro Nakanishi
Case Reports in Pathology.2016; 2016: 1. CrossRef
Gastric adenocarcinoma of the fundic gland (chief cell-predominant type): A review of endoscopic and clinicopathological features
Masaki Miyazawa, Mitsuru Matsuda, Masaaki Yano, Yasumasa Hara, Fumitaka Arihara, Yosuke Horita, Koichiro Matsuda, Akito Sakai, Yatsugi Noda
World Journal of Gastroenterology.2016; 22(48): 10523. CrossRef
Oxyntic gland adenoma endoscopically mimicking a gastric neuroendocrine tumor: A case report
Tae-In Lee
World Journal of Gastroenterology.2015; 21(16): 5099. CrossRef
Oxyntic gland polyp/adenoma
Rajkumar Vajpeyi, Jyoti Dekate
Diagnostic Histopathology.2014; 20(11): 446. CrossRef
Gastric adenocarcinoma of fundic gland type with unusual behavior
Tetsuya Ueo, Hirotoshi Yonemasu, Tetsuya Ishida
Digestive Endoscopy.2014; 26(2): 293. CrossRef

Author index